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In order to investigate the vascular relaxant effect of Ligusticum chuanxiong, Cnidium officinale and Angelicae radix mixed with each of them, we examined with physiography using thoracic aorta of rats. Samples were prepared to be divided Ligusticum chuanxiong (TC), Cnidium officinale (IC), TC removed oil (TCRO), oil extracts from TC (TCO) and IC (ICO), and Angelicae radix (D) mixed with TC (TC/D), IC (IC/D), and TCRO (TCRO/D). From norepinephrine and phenylephrine induced vascular contraction, all the samples had relaxant effect. IC was more effective vascular relaxant capacity compared to TC, however, as removed oil from TC (TCRO) the relaxant capacity was markedly elevated and higher than that of IC. Mixing the Angelicae radix, relaxant effect between TC/D and IC/D was that TC/D was more effective vascular relaxant capacity than that of IC/D. Whereas there was not relaxant effect in TCO and ICO, and TCRO/D was declined in relaxant rotio compared to TCRO. Based on these results, it is suggested that Angelicae radix is very effective material to elevate the vasodilation effect of Ligusticum chuanxiong and Cnidium officinale.
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